Normally human hairs are classified into three basic phases of their growth cycle they 1)anagen, 2)catagen, and 3)telogen. In Anagen phase, hairs are in a growing phase, during that time matrix cells of the hair follicle undergo vigorous mitotic division. In this time hairs have long and roots covered with inner and outer root sheaths, and they are fully pigmented in this stage.
The hair enters the catagen phase, it is a transitional phase in which mitotic activity slightly decreases. The follicles are separated from the dermal papilla and the capillary plexus and then moves upward within its connective tissue sheath to the epidermis, these results telogen hairs, this is a resting phase. In this phase, hairs have short and club-shaped roots that within the follicle. They lack sheaths and show depigmentation of the part of the shaft. The hair continue is in this resting state until the follicle spontaneously enters the anagen phase.
anagen effluvium treatment
The topical minoxidil is not effective in preventing chemotherapy-induced alopecia; it decreases the period of baldness for about 50 days.
Cooling of Scalp may be used, it is accomplished either with cooling agents applied by a cooling cap that is changed several times cooling of the scalp with cold water.
The pressure cuff application around the scalp and local hypothermia retard the anagen arrest if these measures were done during the infusion of medication. These measures do not prevent anagen arrest. The pressure cuff and local hypothermia decrease blood flow in the scalp and affect the delivery of medication to this site.