Defitelio, Ocaliva, Zepatier (FDA APPROVED DRUGS)

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Defitelio (defibrotide sodium)

it is an FDA approved drug, approved in march 2016.

Information about Defitelio:

It is the sodium salt of a mixture single-stranded oligodeoxyribonucleotides. It is derived from porcine mucosal DNA. Which has been shown to have antithrombotic , anti-inflammatory and anti-ischemic properties.

It is mainly indicated for the treatment of the adult and pediatric patients with hepatic veno-occlusive disease (VOD). Sinusoidal ?obstruction syndrome (SOS), with renal and pulmonary dysfunction following hematopoietic stem cell transplantation.

It is supplied intravenously. The recommended dose is 6.25mg/kg every 6hrsgiven as a 2hrs intravenous infusion. A treat for a minimum of 24 days.

Defitelio Side effects:

Adverse effects associated with this drug is

  • Diarrhea
  • Vomiting
  • Nausea
  • Epistaxis
  • Hypotension

Mechanism of action:

It enhances the enzymatic activity of plasmin to hydrolyse the fibrin clots in vitro. The exact mechanism of this drug is not fully understood.

 

Ocaliva (obeticholic acid)

it is an FDA approved drug, approved in may 2016.

Information about ocaliva:

Ocaliva is a farnesoid X receptor (FXR) agonist. It is primarily indicated for the treatment of primary biliary cholangitis (PBC). The combination with ursodeoxycholic acid (UDCA) in adults.

Ocaliva Side effects:

  • Fatigue
  • Abdominal pain and discomfort
  • Rash
  • Dizziness
  • Constipation
  • Arthralgia
  • Thyroid function abnormality
  • Eczema

Mechanism of action:

It is a farnesoid X receptor agonist. FXR is the key regulator of the bile acid. Inflammatory, fibrotic, and metabolic pathways.? FXR decreases the intracellular hepatocyte concentration of bile acids by suppressing de novo synthesis from cholesterol as well as by increased concentration of bile acids out of the hepatocytes.

 

Zepatier (elbasvir and grazoprevir)

it is an FDA approved drug, approved in January 2016.

Information about zepatier:

It is fixed-dose combination product containing elbasvir, a hepatitis c virus (HCV) NS5A inhibitor, and the protease inhibitor.

It is specifically indicated along with the combination of ribavirin for the treatment of the chronic HCV genotype 1 or 4 infections in adults.

It is a tablet or the oral administration. It is to be taken once a day with or without food. See the drug label for the dosage regimen.

zepatier Side effects:

Adverse effects associated with the use of zepatier may include

  • Nausea
  • Headache
  • Fatigue
  • Anemia

Mechanism of action:

It is a fixed-dose combination product containing elbasvir, a hepatitis c virus (HCV) NS5A inhibitor, and the protease inhibitor.

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