Methadone (Dolophine): Uses, Dosage & Side Effects

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Methadone (Dolophine) belongs to the opioids, opioids can also called narcotics. It can reduce the withdrawal symptoms in patients addicted to heroin or other narcotic drugs.

It is mainly used to treat moderate and severe pain

Information about Methadone:

It can slow or stop your breathing, never use these medicines in large amounts or for longer periods, do not crush or break the extended-release tablets because the stability of it gets lost.

it is a habit forming drug. It can be used as the exactly how the doctor has prescribed, directions written on the prescription label should be followed by the patient. It is not to be used in small or large doses and also no longer than prescribed.  Misuse of narcotic drugs can cause addiction, overdose, or death, especially in the case of children and elderly patients. Do not drink alcohol in the course because it can increase side effects.

Dosage pattern of Methadone:


Parenteral: it is about 2.5-10mg for every 8-12hrs as directed by the physician


Initial dose: it is about 20-30mg to be taken orally

Maximum dose: 30mg

Tablets: 2-4mg to be taken orally for every 4-6hrs

A gradual increase in dose may require in the conditions of analgesia is inadequate or if the pain severity increases. Patients with the renal and hepatic impairment can start on a lower starting dose.

Methadone overdose:

The symptoms are life-threatening, seek medical emergency immediately

Symptoms include:

  • Decreased awareness
  • Increased sensitivity
  • No muscle movement
  • Sleepiness
  • Unusual drowsiness

Methadone withdrawal symptoms:

Methadone side effects:

Severity: major

  • Convulsions
  • Blurred vision
  • Decreased urination
  • Dry mouth
  • Decreased urination
  • chest pain
  • rapid breathing
  • severe stomach pain
  • trouble breathing
  • vomiting
  • unusual tiredness
  • stiff neck
  • mental changes
  • irregular heartbeat

Severity: minor

  • nausea
  • difficulty in muscle movement
  • joint pains
  • difficulty in bowel movement
  • acidic stomach
  • back pain
  • indigestion
  • irritability
  • muscle spasm
  • stomach discomfort
  • being forgetful
  • bleeding
  • changes in speech
  • clumsiness

Methadone: brand names, price list


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