Ondansetron (Zofran) : Uses, Dosage & Side Effects

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Ondansetron (Zofran) acts mainly on the chemicals in the body that can trigger nausea and vomiting.

Ondansetron is mainly used to prevent nausea and vomiting which is caused by the surgery, and by the cancer medication

Information about ondansetron:

It is not to be used if the patient using apomorphine and also not to be used in case of allergic to it and also to the medicines such as dolasetron, granisetron, palonosetron , before taking these medicines give information to the doctor if you are having liver disease. It is not to be if allergies started in the body.

Dosage pattern of ondansetron:

Adult dose

Nausea and vomiting induced by chemotherapy

It is about 0.15mg/kg doses, the first dose is infused over 15min before the chemotherapy, another doses administered up 4-8hrs after the first dose.

Usual adult for nausea/vomiting:

It is about 0.15mg/kg doses, the first dose is infused over 15min before the chemotherapy, another doses administered up 4-8hrs after the first dose.

Nausea /vomiting-radiation induced:

8mg to be taken orally for 8hrs, give the first dose 1-2hrs prior to radiotherapy.

Oral: it is about 8mg to be taken for 3 times a day

Pruritis:

It is about 8mg to be taken intravenously before spinal anesthesia

Alcohol dependence:

It is about 4mcg/kg two times a day

Pediatric dose:

Child weight about 40kg: It is about o.1mg in a single dose IV administered over 2-5min,

Child weight about 40kg or above:  it is about 4mg single dose IV, administered over 2-5min.

Ondansetron side effects:

Severity: major

  • Headache
  • Weakness
  • Shortness of breathe
  • Fever
  • Confusion
  • Dizziness
  • Painful urination
  • Decreased urination
  • Lower back pain
  • Cough
  • Loss of appetite
  • Loss of consciousness
  • Nausea
  • Sweating
  • Noisy breathing

Severity: minor

  • Trouble sleeping
  • Restlessness
  • Irritability
  • Hyperventilation
  • Dry mouth
  • Shaking
  • Drooling
  • Loss of balance control
  • Twisting movements in the body

Ondansetron: brand names, price list

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