anisocytosis: Definition, anisocytosis and poikilocytosis, Causes

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(Last Updated On: August 11, 2016)

anisocytosis definition:

anisocytosis is a condition in which the red blood cells of a person are of unequal in size. This normally happens when the patient suffers from Anemia, Thalassemia or any other blood disorder. The blood is tested in such cases, we can see the cells are found to be of different sizes.


Anisocytosis Symptoms

Tiredness is one of the main symptoms of this disease.



shortness of breath

Rapid Heartbeat

The heart beat faster in people suffering from this disease. The heartbeat may increase even without any intense physical activity.

Pale Skin

Affected people normally have an observable paleness of skin. The paleness can be seen in areas of the body such as nail beds and eyeballs.

anisocytosis and poikilocytosis


Anisocytosis is that your RBC is unequal size that indicates some of your red blood cells are either too big or too small (mainly caused by ?anemia). ?iron deficient anemia will usually cause cells to be smaller than normal cell size, Because some of the RBCs are normal size and some are larger, there will be anisocytosis, or RBCs of different sizes.

Poikilocytosis means the blood contain abnormal shaped RBCs. There are many different abnormal shapes (sickle, burr,?tear drop, elliptical). Many of these are due to anemia. There could be other causes, but there is a believe that anemia is one of the more common.

Anisocytosis Causes


?Lack of Vitamin A

Vitamin A is one of the vital nutrients required to the body, which is mainly useful to fight with diseases. Lack of Vitamin A also results in the irregular size of the red blood cells, causing this disease.

Deficiency of Iron

Iron is a very important component required to make blood. Lack of iron can reduce your RBC to a great extent, resulting in anemia, and ultimately leading to this disease.

Vitamin B12 Deficiency

Vitamin B12, just like iron, is a vital component that the body needs to make red blood cells. The decrease in the Vitamin B12 can lead to decreased production of red blood cells resulting in pernicious anemia. This can ultimately give rise to Anisocytosis. Severe lack of Vitamin B12 can lead to nervous disorders.

?Myelodysplastic Syndrome

This disorder can give rise to abnormalities in the bone marrow and blood and lead to a result in the formation of irregular sized blood cells. This is another condition behind Anisocytosis.

Diamond-Blackfan Anemia

Diamond-Blackfan anemia is a condition in which the bone marrow is unable to produce sufficient red blood cells. Anisocytosis may be one of the signs of anemia of this kind.

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