Benadryl(diphenhydramine): Uses, Dosage, Side effects

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(Last Updated On: June 15, 2016)

Benadryl?is an antihistamine, it is mainly used to the sneezing, watery eyes, itching, runny nose, and other symptoms include it can motion sickness, induces sleep and also used to treat mild Parkinson?s disease.

Information about the Benadryl:

Be cautious while the works which needed alertness, it can cause dizziness, drowsiness, alcohol intake may increase the side effects, even more, misuse of this drug can lead to serious side effects. It can be used as the exactly how the doctor has prescribed, directions written on the prescription label should be followed by the patient. It is not to be used in small or large doses and also no longer than prescribed

Dosage pattern of Benadryl:

It is in the form of injection, the dosage should be individualized based on the needs and the response of the patient.

It is about 5mg/kg for 24hrs or 150mg for 24hrs maximum daily dose is 300mg divide it into 4 doses administered intravenously generally 25mg/min,

Adults: 10-50mg intravenously at the rate not exceeding the 25mg/min 100mg if required, the maximum dose is 400mg.

Benadryl side effects:

Nervous system:

Nervous system side effects are have been reported frequently

These include

  • Depression
  • Drowsiness
  • Sedation
  • Motor skills were decreased

Dystonic reactions have been reported after single doses of diphenhydramine. The CNS depressant effects of diphenhydramine parallel its plasma concentrations,

Dystonic reactions have been accompanied by the

  • Dizziness
  • Rigidity
  • Swallowing difficulties
  • Mental confusion
  • Toxic encephalopathy has been reported in a child with chicken pox treated generously with topical diphenhydramine
  • Delirium


  • Rash
  • Pruritus
  • Eczema
  • Photosensitivity reactions


Gastrointestinal side effects have usually mild and included nausea and dry mouth


Cardiovascular side effects include hypotension, tachycardia, and palpitation


Ocular side effects include blurred vision, diplopia, dry eyes, due to anticholinergic effect.


These side effects include hemolytic anemia, thrombocytopenia, and agranulocytosis have been rarely caused by antihistamines.

Benadryl (Diphenhydramine): brand names and price list


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